Original research

Modifying the adult rat tonotopic map with sound exposure produces frequency discrimination deficits that are recovered with training

Training promotes the recovery of electrophysiological measures of reduced neural discriminability following sound exposure.

Chronic downregulation of parvalbumin-positive cell activity accelerates early perceptual learning but impairs end performance

These findings suggest that PV+ cells regulate perceptual learning, "for better and for worse".

PET Imaging of Perceptual Learning-Induced Changes in the Aged Rodent Cholinergic System

Learning led to region-specific changes in cholinergic neurotransmission, as detected by PET imaging and immunohistochemistry.

Reactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneurons

'Manipulating a specific type of neuron in the auditory cortex of rats can restore their brain plasticity.' ~ Futurity

A Brain without Brakes; Reduced Inhibition Is Associated with Enhanced but Dysregulated Plasticity in the Aged Rat Auditory Cortex

'They say you can’t teach old dogs new tricks, but new research shows you can teach an old rat new sounds' ~ NeuroscienceNews

Pairing Cholinergic Enhancement With Perceptual Training Promotes Recovery of Age-Related Changes in Rat Primary Auditory Cortex

Combining auditory training with neuromodulation can restore many of the functional deficits observed as a result of normal aging.

Cortical plasticity

Development, learning, aging and the brain

Self-reported Quality of Life in Pharmacoresistant Temporal Lobe Epilepsy; Correlation With Clinical Variables and Memory Evaluation

Objective testing revealed specific memory deficits that were not reflected in self-reported Quality of Life scores

Impact of the implementation of the AAN epilepsy quality measures on the medical records in a university hospital

A simple intervention led to a better practice standardization and documentation for diagnostic and counseling purposes